Papers

文献年份出版刊物 - 最新优先


  • High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

    Li T, Lu G, Chiang E.Y., Chernov-Rogan T., Grogan J.L., Chen J.

    PLoS ONE 2017, 12(7): e0180154. https://doi.org/10.1371/journal.pone.0180154

  • Evaluation of the antimicrobial activity of the mastoparan Polybia-MPII isolated from venom of the social wasp Pseudopolybia vespiceps testacea (Vespidae, Hymenoptera)

    Silva J.C., Neto L.M., Neves R.C., Gonçalves J.C., Trentini M.M., Mucury-Filho R., Smidt K.S., Fensterseifer I.C., Silva O.N., Lima L.D., Clissa P.B., Vilela N., Guilhelmelli F., Silva L.P., Rangel M., Kipnis A., Silva-Pereira I., Franco O.L., Junqueira-Kipnis A.P., Bocca A.L., Mortari M.R.

    International Journal of Antimicrobial Agents 2017, 49(2):167–175

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  • Polydim-I antimicrobial activity against MDR bacteria and its model membrane interaction

    Rangel1 M., Fernandes dos Santos Castro F., Mota-Lima L.D., Clissa P.B., Martins D.B., Perez dos Santos Cabrera M., Mortari M.R.

    PLoS ONE 2017, 12(6): e0178785

    下载完整论文  (3996.884 kB)
  • Purinergic receptors P2RX4 and P2RX7 in familialmultiple sclerosis

    Sadovnick A.D., Gu B.J., Traboulsee A.L., Bernales C.Q., Encarnacion M., Yee I.M., Criscuoli M.G., Huang X., Ou A., Milligan C.J., Petrou S, Wiley J.S, Vilariño-Güell C.

    Human Mutation 2017, 38(6):736–744

    下载完整论文  (734.456 kB)
  • Gardos Channelopathy: a variant of hereditary Stomatocytosis with complex molecular regulation

    Fermo E., Bogdanova A., etkova-Kirova P., Zaninoni A., Marcello A.P., Makhro A., Hänggi P., Hertz L., Danielczok J., Vercellati C., Mirra N., Zanella A., Cortelezzi A., Barcellini W., Kaestner L., Bianchi P.

    Scientific Reports 2017, 7:1744, doi:10.1038/s41598-017-01591-w

    下载完整论文  (2431.227 kB)
  • Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel

    Ou X., Guo J., Wang L., Yang H., Liu X., Sun J., Liu Z.

    BMC Biol. 2017, 15:31. doi: 10.1186/s12915-017-0372-8

    下载完整论文  (2406.794 kB)
  • Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel

    Arya P, Jarerattanachat V., Clausen M.V., Schewe M., McClenaghan C., Argent L., Conrad L.J., Dong Y.Y., Pike A.C.W., Carpenter E.P., Baukrowitz T., Sansom M.S.P., Tucker S.J.

    Structure 2017, 25(5):708–718.e2

    下载完整论文  (3915.512 kB)
  • Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function.

    Billet A.,Froux L., Hanrahan J.W., Becq F.

    Front Pharmacol. 2017, 8:195

    下载完整论文  (2218.857 kB)
  • 人胚胎干细胞分化的心肌细胞心脏毒性评价模型的建立及应用
    下载完整论文  (1049.083 kB)
  • Myoclonus Epilepsy and Ataxia due to KCNC1 Mutation: Analysis of 20 Cases and K+ Channel Properties

    Oliver K.L., Franceschetti S., Milligan C.J., Muona M., Mandelstam S.A., Canafoglia L., Boguszewska-Chachulska A.M., Korczyn A.D.,Bisulli F., Di Bonaventura C., Ragona F., Michelucci R., Ben-Zeev B., Straussberg R., Panzica F., Massano J., Friedman D., Crespel A., Engelsen B.A., Andermann F., Andermann E., Spodar K., Lasek-Bal A., Riguzzi P.,Pasini E., Tinuper P., Licchetta L., Gardella E., Lindenau M., Wulf A., Møller R.S.

    Annals of Neurology 2017, 81(5):677-689 DOI: 10.1002/ana.24929

    下载完整论文  (3529.82 kB)
  • Structural and electrophysiological dysfunctions due to increased endoplasmic reticulum stress in a long-term pacing model using human induced pluripotent stem cell-derived ventricular cardiomyocytes

    Cui C., Geng L., Shi J., Zhu Y., Yang G., Wang Z., Wang J., Chen M.

    Stem Cell Research & Therapy 2017, 8:109, DOI 10.1186/s13287-017-0566-6


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  • Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation.

    Shah N.R., Wilkinson C., Harborne S.P.D., Turku A., Li K.-M., Sun Y.-J., Harris S., Goldman A.

    Structural Dynamics 2017, 4:032105. doi: http://dx.doi.org/10.1063/1.4978038

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  • Discovery of Compounds that Positively Modulate the High Affinity Choline Transporter.

    Choudhary P., Armstrong E.J., Jorgensen C.C., Piotrowski M., Barthmes M., Torella R., Johnston S.E., Maruyama Y., Janiszewski J.S., Storer R.I., Skerratt S.E., Benn C.L.

    Frontiers in Molecular Neuroscience 2017, 10:40. doi: 10.3389/fnmol.2017.00040

    下载完整论文  (1984.873 kB)
  • Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

    Chiang E.Y., Li T., Jeet S., Peng I., Zhang J., Lee W. P., DeVoss J., Caplazi P., Chen J., Warming S., Hackos D. H., Mukund S., Koth C. M., Grogan J. L.

    Nature Communications 2017, 8: 14644, doi:10.1038/ncomms14644

    下载完整论文  (2678.048 kB)
  • Engineering a pH responsive pore forming protein

    Kisovec M., Rezelj S., Knap P., Cajnko M.M., Caserman S., Flašker A., Žnidaršič N., Repič M., Mavri J., Ruan Y., Scheuring S., Podobnik M., Anderluh G.

    Nature Scientific Reports. 2017, 7:42231

    下载完整论文  (1956.176 kB)
  • Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimers disease

    Kim T., Yang H.Y., Park B.G., Jung S.Y., Park J.H., Park K.D., Min S.J., Tae J., Yang H., Cho S., Cho S.J., Song H., Mook-Jung I., Lee J., Pae A.N.

    Eur J Med Chem. 2017, 125: 1172-1192

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  • Electrophysiology of Respiratory Chain Complexes and the ADP-ATP Exchanger in Native Mitochondrial Membranes
    下载完整论文  (1945.229 kB)
  • L-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes

    Wu J., Wang X., Chung Y.Y. Koh C.H. Liu Z., Guo H., Yuan Q., Wang C., Su S., Wei1 H.

    PLoS ONE 2017, 12(1): e0168435

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  • The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor

    Survery S., Moparthi L., Kjellbom P., Högestätt E.D., Zygmunt P.M., Johanson U.

    The Journal of Biological Chemistry 2016, 291(52): 26899-26912

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  • Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism

    Li K., Wilkinson C., Kellosalo J., Tsai J., Kajander T, Jeuken L.J.C., Sun Y., Goldman A.

    Nature Communications 2016;  7:13596

    下载完整论文  (1892.217 kB)
  • Validation of ADAM10 metalloprotease as a Bacillus thuringiensis Cry3Aa toxin functional receptor in Colorado potato beetle (Leptinotarsa decemlineata)

    Ruiz-Arroyo V.M., Garcıa-Robles I., Ochoa-Campuzano C., Goig G.A., Zaitseva E., Baaken G., Martınez-Ramırez A.C., Rausell C., Real M.D.

    Insect Molecular Biology 2016 December 5;  doi: 10.1111/imb.12285

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  • Alamethicin Supramolecular Organization in Lipid Membranes from 19F Solid-State NMR

    Salnikov E.S., Raya J, De Zotti M, Zaitseva E., Peggion C., Ballano G., Toniolo C., Raap J., Bechinger B.

    Biophysical Journal 2016 December 6;  Volume 111, Issue 11, p2450–2459

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  • Conductance and Capacity of Plain Lipid Membranes under Conditions of Variable Gravity

    Sieber M., Kaltenbach S., Hanke W., Kohn F.P.M.

    J. Biomedical Science and Engineering 2016;  9:361-366

    下载完整论文  (695.668 kB)
  • Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

    Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Mueller M, Stiehler J, George M, Fertig N

    JALA  2016; 21(6):779-793; DOI: 10.1177/2211068215623209 (Epub 2015 Dec 23)

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  • Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel

    Vaisey G, Miller AN, Long SB

    PNAS 2016; doi: 10.1073/pnas.1614688113

    下载完整论文  (1671.946 kB)
  • The N-terminal Ankyrin Repeat Domain Is Not Required for Electrophile and Heat Activation of the Purified Mosquito TRPA1 Receptor

    Survery S, Moparthi L, Kjellbom P, Högestätt ED, Zygmunt PM, Johanson U

    J Biol. Chem. 2016; doi: 10.1074/jbc.M116.743443

    下载完整论文  (2683.568 kB)
  • Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation

    Lorberbaum T, Sampson KJ, Chang JB, Iyer V, Woosley RL, Kass RS, Tatonetti NP

    Am Coll Cardiol. 2016; 68(16):1756-1764. doi:10.1016/j.jacc.2016.07.761

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  • Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola

    Dhakshnamoorthy B, Rohaim A, Rui H, Blachowicz L, Roux B

    Nature Communications 2016, 7:12753, doi: 10. 1038/ncomms12753  

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  • Safety pharmacology studies using EFP and impedance

    Obergrussberger A, Juhasz K, Thomas U,Stölzle-Feix S, Becker N, Dörr L, Beckler M, Bot C, George M, Fertig N

    Journal of Pharmacological and Toxicological Methods (2016) 81:223-232  

    下载完整论文  (2127.393 kB)
  • Identification of Drug-Drug Interactions In Vitro: A Case Study Evaluating the Effects of Sofosbuvir and Amiodarone on hiPSC-Derived Cardiomyocytes

    Millard DC, Strock CJ, Carlson CB, Aoyama N, Juhasz K, Goetze TA, Stoelzle-Feix S, Becker N, Fertig N, January CT, Anson BD, Ross JD.

    Toxicol Sci 2016 doi: 10.1093/toxsci/kfw153, ahead of print 

    下载完整论文  (913.475 kB)
  • Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1

    Briones R, Weichbrodt C,Paltrinieri L, Mey I, Villinger S, Giller K, Lange A, Zweckstetter M, Griesinger C, Becker S, Steinem C, de Groot BL

    Biophysical Journal 2016 Sep 20, 111:1223-1234  

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  • Use-dependent Block of Human Cardiac Sodium Channels by GS967

    Potet F, Vanoye CG, George Jr. AL.

    Mol. Pharmacol. 2016 July 90(1):52-60. doi: 10.1124/mol.116.103358  

    下载完整论文  (754.339 kB)
  • Human T cells in silico: Modelling their electrophysiological behaviour in health and disease

    Ehling P, Meuth P, Eichinger P, Hermann AM, Bittner S, Pawlowski M, Pankratz S, Herty M, Budde T, Meuth SG.

    J. Theor. Biol. 2016 Sep 7; 404:236-50. doi: 10.1016/j.jtbi.2016.06.001. Epub 2016 Jun 8.

    下载完整论文  (1393.809 kB)
  • The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts

    Petty SJ, Milligan CJ, Todaro M, Richards KL, Kularathna PK, Pagel CN, French CR, Hill-Yardin EL, O"Brien TJ, Wark JD, Mackie EJ, Petrou S.

    Epilepsia. 2016 July [epub ahead of print] doi: 10.1167/iovs.16-19170.

    下载完整论文  (619.811 kB)
  • Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

    Vasas A, Forgo P, Orvos P, Tálosi L, A Csorba A, Pinke G, Hohmann J.

    J. Nat. Prod. 2016 July [epub ahead of print] DOI: 10.1021/acs.jnatprod.6b00260  

    下载完整论文  (1292.378 kB)
  • Mechanistic signs of double-barreled structure in a fluoride ion channel

    Last NB, Kolmakova-Partensky L, Shane T, Miller C 

    eLife. 2016;5:e18767. DOI:10.7554/eLife.18767.

    下载完整论文  (1938.793 kB)
  • pH-sensitive K+ channel TREK-1 is a novel target in pancreatic cancer

    Sauter DRP, Sørensen CE, Rapedius M, Brüggemann A, Novak I

    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2016 Jul 19. pii: S0925-4439(16)30177-6. doi: 10.1016/j.bbadis.2016.07.009. 

    下载完整论文  (1143.525 kB)
  • Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity.

    Moparthi L., Kichko T. I., Eberhardt M., Högestätt E. D., Kjellbom P., Johanson U., Reeh P., W., Leffler A., Filipovic M. R., Zygmunt P. M.

    Scientific Reports. 2016, 6:28763. doi: 10.1038/srep28763.

    下载完整论文  (1365.559 kB)
  • Conductance and Capacity of Plain Lipid Membranes under Conditions of Variable Gravity

    Sieber M., Kaltenbach S., Hanke W. and Kohn F.P.M

    JBiSE. 2016 July 1; 9, 361-366.

    下载完整论文  (687.02 kB)
  • Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca2+ Influx Dysfunction in Human Pterygial Cells

    Garreis F, Schröder A, Reinach PS, Zoll S, Khajavi N, Dhandapani P, Lucius A, Pleyer U, Paulsen F, Mergler S.

    Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2564-77. doi: 10.1167/iovs.16-19170.

    下载完整论文  (3474.166 kB)
  • Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

    Barthmes M, Liao J, Jiang Y, Brüggemann A, and Wahl‑Schott C.

    JGP. 2016 May 30 ;147(6):485-496. doi: 10.1085/jgp.201611587

    下载完整论文  (2168.475 kB)
  • Photosensitization in Porphyrias and Photodynamic Therapy Involves TRPA1 and TRPV1

    Babes A, Sauer SK, Moparthi L, Kichko TI, Neacsu C, Namer B, Filipovic M, Zygmunt PM, Reeh PW, Fischer MJ.

    J Neurosci. 2016 May 11;36(19):5264-78. doi: 10.1523/JNEUROSCI.4268-15.2016.

  • Safety pharmacology studies using EFP and impedance

    Obergrussberger A, Juhasz K, Thomas U, Stölzle-Feix S, Becker N, Dörr L, Beckler M, Bot C, George M, Fertig N.

    J Pharmacol Toxicol Methods. 2016 Apr 12. pii: S1056-8719(16)30033-8. doi: 10.1016/j.vascn.2016.04.006.

  • Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

    Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S

    Sci Rep. 2016 Mar 23;6:23417. doi: 10.1038/srep23417.

    下载完整论文  (1994.392 kB)
  • Reversible control of current across lipid membranes by local heating

    Urban P, Kirchner SR, Mühlbauer C, Lohmüller T, Feldmann J

    Sci Rep. 2016 Mar 4;6:22686. doi: 10.1038/srep22686.

    下载完整论文  (913.036 kB)
  • Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

    Rajamohan D, Kalra S, Hoang MD, George V, Staniforth A, Russell H, Yang X, Denning C.

    Stem Cells Dev. 2016 Feb 23. 下载完整论文  (906.781 kB)
  • Defined Medium Conditions for the Induction and Expansion of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium

    Lidgerwood GE, Lim SY, Crombie DE, Ali R, Gill KP, Hernández D, Kie J, Conquest A, Waugh HS, Wong RC, Liang HH, Hewitt AW, Davidson KC, Pébay A.

    Stem Cell Rev. 2015 Nov 20. DOI 10.1007/s12015-015-9636-2

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  • A biomimetic DNA-made channel for the ligand-controlled and selective transport of small-molecule cargo through a biological membrane

    Burns J.R., Seifert A., Fertig N, Howorka S

    Nature Nanotechnology 2016 February 11 doi: 10.1038/nnano.2015.279.

    下载完整论文  (2350.518 kB)
  • Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp

    Haraguchi Y, Ohtsuki A,2, Oka T, Shimizu T.

    BMC Pharmacol Toxicol. 2015 Dec 16;16(1):39. doi: 10.1186/s40360-015-0042-9.

    下载完整论文  (1879.496 kB)
  • Automated Patch Clamp Meets High-Throughput Screening: 384 Cells Recorded in Parallel on a Planar Patch Clamp Module

    Obergrussberger A, Brüggemann A, Goetze TA, Rapedius M, Haarmann C, Rinke I, Becker N, Oka T, Ohtsuki A, Stengel T, Vogel M, Steindl J, Mueller M, Stiehler J, George M, Fertig N

    J Lab Autom. 2015 Dec 23. pii: 2211068215623209.

  • Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system

    T Soranzo, S Cortes, F Gilde et. al.

    Protein Expression and Purification, 2016, 118, 83-91

    下载完整论文  (1415.677 kB)
  • Novel screening techniques for ion channel targeting drugs

    A Obergrussberger, S Stoelzle-Feix, Nadine Beckeret. al.

    Channels, 2015, 9(6), 1-9

    下载完整论文  (854.425 kB)
  • Improvement of Chloride Transport Defect by Gonadotropin-Releasing Hormone (GnRH) in Cystic Fibrosis Epithelial Cells

    N Benz, S Le Hir, C Norez, et al

    PLoS One 2014, 9(2): e88964

    下载完整论文  (1895.335 kB)
  • Quantification of Fluoroquinolone Uptake through the Outer Membrane Channel OmpF of Escherichia coli

    J Cama, H Bajaj, S Pagliara et al

    J. Am. Chem. Soc., Article ASAP, Oct. 19, DOI:10.1021/jacs.5b08960

    下载完整论文  (1031.391 kB)
  • Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β1 modulatory subunit of the BKCa channel

    Jacob E. McMillan, Anna N. Bukiya, Camisha L. Terrell et al

    Journal of Molecular Graphics and Modelling, 2014, 54, 174-183 

    下载完整论文  (1664.678 kB)
  • The Functional Property Changes of Muscular Nav1.4 and Cardiac Nav1.5 Induced by Scorpion Toxin BmK AGP-SYPU1 Mutants Y42F and Y5F

    Xiangxue Meng, Yijia Xu, Mingyi Zhao, Fangyang Wang, Yuanyuan Ma, Yao Jin, Yanfeng Liu, Yongbo Song, and Jinghai Zhang

    Biochemistry 2015, 54, 2988-2996

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  • High-Resolution Size-Discrimination of Single Nonionic Synthetic Polymers with a Highly Charged Biological Nanopore

    Gerhard Baaken, Ibrahim Halimeh, Laurent Bacri, Juan Pelta, Abdelghani Oukhaled, and Jan C. Behrends

    ACS Nano, 2015, 9(6), 6443-6449

  • Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes As Revealed by Intrinsic Tryptophan Fluorescence Quenching

    Billen B, Brams M, Debaveye S, Remeeva A, Alpizar YA, Waelkens E, Kreir M, Brüggemann A, Talavera K, Nilius B, Voets T, Ulens C.

    J Biol Chem. , 2015 Mar 31. pii: jbc.M114.628925.

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  • Antibiotic translocation through porins studied in planar lipid bilayers using parallel platforms

    C Weichbrodt, H Bajaj, G Baaken, J Wang, S Guinot, M Kreir, JC Behrends, M Winterhalter and N Fertig

    Analyst, 2015, Advance Article, doi: 10.1039/C4AN02335H

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  • Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

    Moparthi L, Survery S, Kreir M, Simonsen C, Kjellbom P, Högestätt ED, Johanson U, Zygmunt PM.

    Proc Natl Acad Sci U S A. 2014 111(47):16901-6.

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  • Membrane assembly of the functional KcsA potassium channel in a vesicle-based eukaryotic cell-free translation system

    Dondapati SK, Kreir M, Quast RB, Wüstenhagen DA, Brüggemann A, Fertig N, Kubick S.

    Biosens Bioelectron 2014, 15(59), 174-83

  • K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

    Y.Y. Dong, A.C. W. Pike, A. Mackenzie et al

    Science, 2015, 347 (6227), pp. 1256-1259

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  • Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment

    Y. Sakurai, A. A. Kolokoltsov, C.-C. Chen et al

    Science, 2015, 347 (6225), pp. 995-998

    下载完整论文  (1770.705 kB)
  • Cell-free expression of a functional pore-only sodium channel

    Kovácsová G, Gustavsson E, Wang J, Kreir M, Peuker S, Westenhoff S.

    Protein Expr Purif. 2015,  Mar 11. pii: S1046-5928(15)00042-X.  doi: 10.1016/j.pep.2015.03.002. [Epub ahead of print]

    下载完整论文  (962.923 kB)
  • Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy

    Friedrichs S, Malan D,Voss Y and Sasse P.

    J. Clin. Med.. 2015, 4, 102-123; doi:10.3390/jcm4010102

    下载完整论文  (602.835 kB)
  • New Easy-to-Use Hybrid System for Extracellular Potential and Impedance Recordings

    Doerr L, Thomas U, Guinot DR, Bot CT, Stoelzle-Feix S, Beckler M, George M, Fertig N.

    J Lab Autom. 2014 Dec 22. pii: 2211068214562832

    下载完整论文  (7658.521 kB)
  • L-Carnitine Reduces in Human Conjunctival Epithelial Cells Hypertonic-Induced Shrinkage through Interacting with TRPV1 Channels

    Noushafarin Khajavi, Peter S. Reinach, Marek Skrzypski, Anja Lude, Stefan Mergler

    Cell Physiol Biochem 2014, 34, 790-803

    下载完整论文  (1962.738 kB)
  • Physiological and genetic analysis of multiple sodiumchannel variants in a model of genetic absence epilepsy

    Oliva MK, McGarr TC, Beyer BJ, Gazina E, Kaplan DI, Cordeiro L, Thomas E, Dib-Hajj SD, Waxman SG, Frankel WN, Petrou S.

    Neurobiol Dis. 2014 Jul;67:180-90. doi: 10.1016/j.nbd.2014.03.007. Epub 2014 Mar 19.

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  • Bilayer-Spanning DNA Nanopores with Voltage-Switching between Open and Closed State

    A Seifert, K Göpfrich, J R Burns, N Fertig, UF Keyser, and S Howorka

    ACS Nano2014,DOI: 10.1021/nn5039433, Publication Date (Web): 22 Oct 2014

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  • New strategies in ion channel screening for drug discovery: are there ways to improve its productivity

    C. Farre & N. Fertig

    Expert Opinion on Drug Discovery 2014,  9 (10), 1-5

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  • Early identification of hERG liability in drug discovery programs by automated patch clamp

    Danker T and Moeller C.

    Front. Pharmacol. doi: 10.3389/fphar.2014.00203

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  • Crystal structure of a human GABAA receptor

    Paul S. Miller & A. Radu Aricescu

    Nature 2014 Aug 21, 512, 270–275, doi:10.1038/nature13293

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  • Structure and mechanistic insights into the bacterial amyloid secretion channel CsgG

    Goyal P, Krasterva PV, Gerven N V et al.

    Nature. 2014 Sept 14; doi: 10.1038/nature13768.

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  • A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV

    Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C.

    Nat Commun. 2014 Aug 14;5:4681. doi: 10.1038/ncomms5681.

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  • High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

    Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz B, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

    Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.

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  • Automated Formation of Lipid Membrane Microarrays for Ionic Single-Molecule Sensing with Protein Nanopores

    Del Rio Martinez JM, Zaitseva E, Petersen S, Baaken G, Behrends JC.

    Small. 2014 Aug 13. doi: 10.1002/smll.201402016. [Epub ahead of print]

  • KCNMA1 Encoded Cardiac BK Channels Afford Protection against Ischemia-Reperfusion Injury

    Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R.

    PLoS One. 2014 Jul 29;9(7):e103402. doi: 0.1371/journal.pone.10103402. eCollection 2014.

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  • Anticancer Ruthenium(III) Complex KP1019 Interferes with ATP-Dependent Ca2+ Translocation by Sarco-Endoplasmic Reticulum Ca2+-ATPase (SERCA)

    Sadafi FZ, Massai L, Bartolommei G, Moncelli MR, Messori L, Tadini-Buoninsegni F.

    ChemMedChem. 2014 Aug;9(8):1660-4. doi: 10.1002/cmdc.201402128. Epub 2014 Jun 11.

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  • Structure of a Conserved Golgi Complex-targeting Signal in Coronavirus Envelope Proteins

    Y Li,W Surya,S Claudine and J Torres

    J. Biol. Chem., 2014 289, 12535-12549

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  • An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity

    O. Danilchankaa,J. Suna,M. Pavlenok et al.

    PNAS USA, 2014 111(18), 6750–6755, doi: 10.1073/pnas.1400136111

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  • Calcium regulation by temperature-sensitive transient receptor potential channels in human uveal melanoma cells

    Mergler S, Derckx R, Reinach PS, Garreis F, Böhm A, Schmelzer L, Skosyrski S, Ramesh N, Abdelmessih S, Polat OK, Khajavi N, Riechardt AI.

    Cell Signal. 2014 Jan;26(1):56-69. doi: 10.1016/j.cellsig.2013.09.017. Epub 2013 Sep 29.

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  • Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

    M.K. Olivaa,T.C. McGarrb,B.J. Beyer et al.

    Neurobiology of disease, 2014 67:180 -90.

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  • Characterizing Human Ion Channels in Induced Pluripotent Stem Cell-Derived Neurons
    Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, Brüggemann A, Fertig N.

    J Biomol Screen. 2012 Oct;17(9):1264-72. Epub 2012 Aug 24.

    Figure_2

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  • Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs

    Takahara A, Fujiwara K, Ohtsuki A, Oka T, Namekata I, Tanaka H.

    J Pharmacol Sci. 2012 Nov 16;120(3):165-75.

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  • Toward a new gold standard for early safety: automated temperature-controlled hERG test on the Patchliner

    Polonchuk L

    Frontiers in Pharmacology, 2012, Vol 3, Article 3, 1-7

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  • Design, synthesis and functional analysis of dansylated polytheonamide mimic: an artificial Peptide ion channel

    Itoh H., Matsuoka S., Kreir M., Inoue M.

    J. Am. Chem. Soc. 134, 14011, 2012

  • Insulin-secreting INS-1E cells express functional TRPV1 channels

    Fågelskiöld A.J., Kannisto K., Boström A., Hadrovic B., Farre C., Eweida M., Wester K.and Islam MD.S.

    Islets. 4:1, 1–8, January/February 2012

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  • Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP

    Zong X, Krause S, Chen CC, Krüger J, Gruner C, Cao-Ehlker X, Fenske S, Wahl-Schott C, Biel M.

    J Biol Chem., 2012 Aug, 3;287(32):26506-12.

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  • TRPA1 Agonist Activity of Probenecid Desensitizes Channel Responses: Consequences for Screening

    McClenaghan C, Zeng F, Verkuyl JM

    Assay Drug Dev Technol., 2012 Jun 8

  • DNA unzipping and protein unfolding using nanopores

    Merstorf C, Cressiot B, Pastoriza-Gallego M, Oukhaled AG, Bacri L, Gierak J, Pelta J, Auvray L, Mathé J.

    Methods Mol Biol. 2012;870:55-75.

  • Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels

    Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ.

    Biochem Pharmacol. 2012 Aug 15;84(4):540-8

  • Interleukin-1R3 mediates interleukin-1–induced potassium current increase through fast activation of Akt kinase

    Qian J, Zhu L, Li Q, Belevych N, Chen Q, Zhao F, Herness S, Quan N.

    Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12189-94

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  • Hydrophobic gating of mechanosensitive channel of large conductance evidenced by single-subunit resolution

    Birkner JP, Poolman B, Koçer A.

    Proc Natl Acad Sci USA. 2012 Aug 7;109(32):12944-9

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  • Synthesis and in vitro antibacterial activity of novel 3-azabicyclo[3.3.0]octanyl oxazolidinones

    Bhattarai D, Lee SH, Seo SH, Nam G, Kang SB, Pae AN, Kim EE, Oh T, Cho SN, Keum G.

    Chem Biol Drug Des. 2012 Sep;80(3):388-97

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  • Observation of Antinociceptive Effects of Oxymatrine and its Effect on Delayed Rectifier K+ Currents (Ik) in PC12 Cells

    Wang Y, Yuan J, Yuan X, Wang W, Pei X, Zhao Q, Cao H, Xu M, Liu Z.

    Neurochem Res., 2012, Jul 20

  • Natural and artificial ion channels for biosensing platforms

    Steller L., Kreir M., Salzer R.

    Anal Bioanal Chem. (2012) 402:209–230

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  • Selective modification of the N-Terminal structure of polytheonamide B significantly changes its cytotoxicity and activity as an ion channel
    Shinohara N, Itoh H, Matsuoka S, and Inoue M

    ChemMedChem, published online April 4th, 2012

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  • Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells

    Stefan Mergler, Fabian Garreis, Monika Sahlmüller, Ekaterini-Maria Lyras,

    Peter S. Reinach, Abhilash Dwarakanath, Friedrich Paulsen, Uwe Pleyer

    Histochem. Cell. Biol., Published online February 12 2012

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  • HTS techniques for patch clamp-based ion channel screening - advances and economy

    Farre C and Fertig N

    Expert Opin. Drug Disc. early online publication April 2012

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  • Chimeric approach reveals that differences in the TRPV1 pore domain determine species-specific sensitivity to block of heat activation
    Papakosta M., Dalle C., Haythornthwaite A., Cao L., Stevens E.B., Burgess G., Russell R., Cox P.J., Phillips S.C., Grimm C.

    J. Biol. Chem., 2011 Sep 12. [Epub ahead of print]

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  • Thermosensitive transient receptor potential channels in human corneal epithelial cells

    Mergler S., Garreis F., Sahlmüller M., Reinach P.S., Paulsen F., and Pleyer U.

    J. Cell. Physiol., 2011, 226, 1828 - 1842 

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  • Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels
    Majeed Y, Bahnasi Y, Seymour VAL, Wilson LA, Milligan CJ, Agarwal AK, Sukumar P, Naylor J, and
    Beech DJ 

    Mol. Pharmacol., 79(6),1023-30, 2011

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  • Nanopore-based single-molecule mass spectrometry on a lipid membrane microarray

    Baaken G., Ankri N., Schuler A.K., Rühe J., Behrends C.

    Am. Chem. Soc Nano, 5(10), 8080-8088, 2011

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  • Green fluorescent protein changes the conductance of connexon 43 hemichannels reconstituted in planar lipid bilayers
    Christian Carnarius , Mohamed Kreir, Marcel Krick, Christoph Methfessel, Volker Moehrle, Oliver Valerius, Andrea Brüggemann, Claudia Steinem, Niels Fertig

    Journal of Biological Chemistry, Published on December 3, 2011 as Manuscript M111.319871

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  • State-of-the-art automated patchclamp devices: heatactivation, actionpotentials, and highthroughput in ionchannel screening

    Sonja Stoelzle, Alison Obergrussberger, Andrea Brüggemann, Claudia Haarmann, Michael George, Ralf Kettenhofen and Niels Fertig

    Frontiers in Pharmacology, November 2011, Volume 2 , Article 76

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  • Automated electrophysiology makes the pace for cardiac ion channel safety screening

    Clemens Möller, Harry Witchel

    Frontiers in Pharmacology, November 2011, Volume 2, Article 73

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  • Thermo-sensitive transient receptor potential vanilloid channel-1 regulates intracellular calcium and triggers chromogranin A secretion in pancreatic neuroendocrine BON-1 tumor cells
    Stefan Mergler, Marek Skrzypski, Maciej Sassek, Piotr Pietrzak, Christina Pucci, Bertram Wiedenmann, Mathias Z. Strowski

    Cellular Signalling 24 (2012) 233–246

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  • Characterization of transient receptor potential vanilloid channel 4 (TRPV4) in human corneal endothelial cells

    Stefan Mergler,, Monika Valtink, Katrin Taetz, Monika Sahlmüller, Gabriele Fels, Peter S. Reinach, Katrin Engelmann and Uwe Pleyer

    Experimental Eye Research 93 (2011) 710e719

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  • Development of a selective small-molecule inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel
    Gautam Bhave1, Brian A. Chauder1, Wen Liu2, Eric S. Dawson1, Rishin Kadakia1, Thuy T. Nguyen1, L. Michelle Lewis1, Jens Meiler1, C. David Weaver1, Lisa M. Satlin2, Craig W. Lindsley1 and Jerod S. Denton1, 

    Molecular Pharmacology, 2011, 79(1), 42-50

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  • Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction

    Stoelzle S, Haythornthwaite A, Kettenhofen R, Kolossov E, Bohlen H, George M, Brüggemann A, Fertig N.

    J Biomol Screen. 2011 Jul 20. [Epub ahead of print]
    Image from the paper:

    2011_Stoelzle_small

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  • Physiologie des humanen Hornhautendothels - neue Erkenntnisse durch elektrophysiologische Untersuchungen

    Mergler S. and Pleyer U.

    Klin. Monatsbl. Augenheilkd., 2011, 228, 520 - 524 

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  • Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins

    David Shaya, Mohamed Kreir, Rebecca A. Robbins, Stephanie Wong, Justus Hammon, Andrea Brüggemann, and Daniel L. Minor, Jr

    PNAS Early Edition, 2011, 1 - 6
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    PNAS_2011_single_channels_small

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  • Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques

    Kee-Hyun Choi, Chiman Song, Chan S. Cheong and Hyewhon Rhim

    Gen. Physiol. Biophys., 2011, 30100–105

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  • Chemical and biological characterization of four new linear cationic a-helical peptides from the venoms of two solitary eumenine wasps
    Marisa Rangel, Marcia Perez dos Santos Cabrera, Kohei Kazuma, Kenji Ando, Xiaoyu Wang, Manabu Kato, Ken-ichi Nihei, Izaura Yoshico Hirata, Tyra J. Cross, Angélica Nunes Garcia, Eliana L. Faquim-Mauro, Marcia Regina Franzolin, Hiroyuki Fuchino, Kanami Mori-Yasumoto, Setsuko Sekita, Makoto Kadowaki, Motoyoshi Satake, Katsuhiro Konno

    Toxicon,2011, 57,1081–1092

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  • Book chapter: 'Cardiac Toxicity'

    Ralf Kettenhofen and Silke Schwengberg 

    ADMET for Medicinal Chemists: A Practical Guide, Edited by Katya Tsaioun and Steven A. Kates, John Wiley & Sons, 

    Inc., 2011, 287 - 314

  • Functional analysis of synthetic substructures of polytheonamide B: A transmembrane channel-forming peptide
    Matsuoka S, Shinohara N, Takahashi T, Iida M, and Inoue M 

    Angew. Chem. Int. Ed., 50, 4879 – 4883, 2011

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  • TRPV channels mediate temperature-sensing in human corneal endothelial cells

    Stefan Mergler, Monika Valtink, Vivien Jane Coulson-Thomas, Dirk Lindemann, Peter S. Reinach, Katrin Engelmanng, Uwe Pleyer,

    Experimental Eye Research, 90 (2010) 758e770

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  • Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes
    Michael Schieder, Katrin Rötzer, Andrea Brüggemann, Martin Biel and Christian Wahl-Schott

    Science Signaling, 2010, 3(151), 1-15

     2010ScienceSignaling

    2010-sciencesignaling01-small 2010-sciencesignaling02-small 2010-sciencesignaling03-small

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  • Propranolol blocks cardiac and neuronal voltage-gated sodium channels

    Dao W. Wang, Akshitkumar M. Mistry, Kristopher M. Kahlig, Jennifer A. Kearney, Jizhou Xiang and Alfred L. George Jr., Frontiers in Pharmacology, Original Research Article published: 31 December 2010; doi: 10.3389/fphar.2010.00144

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  • Ircinialactams: subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

    Balansa W, Islam R, Fontaine F, Piggott AM, Zhang H, Webb TI, Gilbert DF, Lynch JW, Capon RJ. 

    Bioorg Med Chem. 2010 Apr 15;18(8):2912-9. Epub 2010 Mar 6.

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  • Cor.At® Cardiomyocytes: Primary-like Cardiomyocytes for Manual and Automated Electrophysiological Screening

    Ralf Kettenhofen1 and Sonja Stoelzle21Axiogenesis AG, Cologne, Germany, 2Nanion Technologies, Munich, Germany

    2010CorAt

    Screenshots from this publication:

    Kettenhofen_Stoelzle2010-smallKettenhofen_Stoelzle2010-02smallKettenhofen_Stoelzle2010-03small

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  • Characterization of two pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes

    Schieder M., Rötzer K., Brüggemann A., Biel M. and Wahl-Schott C.A.: 

    The Journal of Biological Chemistry Vol. 285, No. 28, pp. 21219–21222, July 9, 2010

    Characterization of two pore channel 2 Ca2+ currents

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  • Permeation of antibiotics through escherichia coli OmpF and OmpC porins: screening for influx on a single-molecule level

    Mahendran K.R., Kreir M., Weingart H., Fertig N., Winterhalter M. 

    J. Biomol. Screen., 2010 Jan 19

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  • Multiplexed transposon-mediated stable gene transfer in human cells

    Kahlig K.M., Saridey S.K., Kaja A., Daniels M.A., George A.L. Jr and Wilson M.H. 

    Proc. Natl. Acad. Sci. USA., 2010, Jan 26;107(4), 1343-8.

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  • Renaissance of ion channel research and drug discovery by patch clamp automation

    Farre C. and Fertig N. 

    Future Med. Chem., 2010, 2(5), 1-5.

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  • Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

    Naylor J., Li J., Milligan C.J, Zeng F., Sukumar P., Hou B., Sedo A., Yuldasheva N., Majeed Y., Beri D., Jiang S., Seymour V.A.L, McKeown L., Kumar B., Harteneck C., O\"Regan D., Wheatcroft S.B., Kearney M.T, Jones C., Porter K.E. and Beech D.J. Circ. Res., 2010, published online Apr 10, 1-18.

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  • Studying mechanosensitive ion channels using liposomes

    Martinac B., Rohde P.R., Battle A. R., Petrov E., Pal P, Alexander Foo A.FW, Vásquez V., Huynh T. and Kloda A.

    Methods Mol. Biol. 2010, 606, 31-53.

  • High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1

    Lewis L.M., Bhave G., Chauder B.A., Banerjee S., Lornsen K.A., Redha R., Fallen K., Lindsley C.W., Weaver C.D.,

    Denton J. Mol. Pharmacol., 2009, 76(5), 1094-1103.

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  • Robotic multiwell planar patch-clamp for native and primary mammalian cells

    Milligan C.J., Li J., Sukumar P., Majeed Y., Dallas M.L., English A., Emery P., Porter K.E., Smith A.M., McFadzean I.,

    Beccano-Kelly D., Bahnasi Y., Cheong A., Naylor J., Zeng F., Liu X., Gamper N., Jiang L., Pearson H.A., Peers C., Robertson B., Beech D.J.

    Nature Protocols, 2009, 4(2), 244-255. 


    Screenshots from this publication:

    Images of HEK 293 cellsplanar whole-cell patch-clamp data, HEK 293 cellsPlanar whole-cell patch-clamp data from native and primary cells


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  • Port-a-Patch and Patchliner: High fidelity electrophysiology for secondary screening and safety pharmacology

    Farre C., Haythornthwaite A., Haarmann C., Stoelzle S., Kreir M., George M., Brüggemann A., Fertig N.

    Comb. Chem. & HTS, 2009, 12 (1), 24-37.

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  • Ion channel screening – automated patch clamp on the rise

    Farre C., George M., Brüggemann A., Fertig N.

    Drug Discovery Technology, 2009.

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  • Amyloid-beta-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy

    Capone R., Quiroz F.G., Prangkio P., Saluja I., Sauer A.M., Bautista M.R., Turner R.S., Yang J., Mayer M.

    Neurotox. Res., 2009, 16(1), 1-13. Epub 2009 Mar 19.

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  • The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes

    Gaßmann O., Kreir M., Ambrosi C., Pranskevich J., Oshima A, Röling C., Sosinsky G., Fertig N., Steinem C.

    Journal of Structural Biology, 2009, 168 (1), 168-176.

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  • High throughput techniques for discovering new glycine receptor modulators and their binding sites

    Gilbert D.F.,Islam R., Lynagh T., Lynch J.W., Webb T.I. Front.

    Mol. Neurosci., 2009, 2(17), 1-10. Epub 2009 Oct 30

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  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases

    Bessac B.F., Sivula M., von Hehn C.A., Caceres A.I., Escalera, J, Jordt S.

    FASEB Journal, 2009; 23, 1102-1114.

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  • Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells

    Li J., Sukumar P., Milligan C.J., Kumar B., Ma Z.Y., Munsch C.M., Jiang L.H., Porter K.E., Beech D.J.

    Circ. Res., 2008 103(8), e97-104.

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  • TRPA1 is a major oxidant sensor in murine airway sensory neurons

    Bessac B.F., Sivula M., von Hehn C.A., Escalera J., Cohn L., Jordt S.E.

    J. Clin. Invest., 2008, 118(5), 1899-1910

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  • TRPC channel activation by extracellular thioredoxin

    Xu S.Z., Sukumar P., Zeng F., Li J., Jairaman A., English A., Naylor J., Ciurtin C., Majeed Y., Milligan C.J., Bahnasi Y.M., Al-Shawaf E., Porter K.E., Jiang L.H., Emery P., Sivaprasadarao A., Beech D.J.

    Nature, 2008 451(7174), 69-72.

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  • Production of a specific extracellular inhibitor of TRPM3 channels

    Naylor J., Milligan C.J., Zeng F., Jones C., Beech D.J.

    British Journal of Pharmacology, 2008, 1–7.

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  • Planar patch-clamp force microscopy on living cells

    Pamir E., George M., Fertig N., Benoit M.

    Ultramicroscopy, 2008, 108(6), 552-557.

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  • Book chapter: 'Planar patch clamp – Advances in electrophysiology'

    Brüggemann A., Farre C., Haarmann C., Haythornthwaite A., Kreir M., Stoelzle S., George M., Fertig N.

    Methods in Molecular Biology, Potassium channels, Humana Press, 2008, 49, 165-176.

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  • T-type channel blocking properties and antiabsence activity of two imidazo[1,2-b]pyridazine derivatives structurally related to indomethacin

    Rimoli M.G., Russo E., Cataldi M., Citraro R., Ambrosino P., Melisi D., Curcio A., De Lucia S., Patrignani P., De Sarro G., Abignente E.

    Neuropharmacology, 2008, Nov 30., E-publication ahead of print.

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  • Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes

    Kreir M., Farre C., Beckler M., George M., Fertig N.

    Lab-on-a-Chip, 2008, 8(4), 587-95.

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  • Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3

    Cianci J., Baell J.B., Flynn B.L., Gable R.W., Mould J.A., Paul D., Harvey A.J.

    Bioorganic & Med. Chem. Lett., 2008, 18, 2055–2061.

  • User review of planar electrophysiological devices: 'High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology'
    Dunlop J., Bowlby M., Peri R., Vasilyev D., Arias R.

    Nature Reviews Drug Discovery, 2008, 7, 358-368.

  • New Notable: 'Patch clamp on a chip'

    Biophys. J., 2002, 82(Jun), 2831-2832.

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  • Activity of single ion channel proteins detected with a planar microstructure
    Fertig N., Klau M., George M., Blick R.H., Behrends J.C.

    APL, 2002, 81(25), 4865-67.

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  • New Notable: 'Lighting up single ion channels'

    Biophys. J.; 2003, 84(Jan), 1-2.

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  • Simultaneous optical and electrical recording of single gramicidin channels
    Borisenko V., Lougheed L., Hesse J., Fuereder-Kitzmueller E., Fertig N., Behrends, J.C., Woolley G.A., Schuetz G.J.

    Biophys. J., 2003, 84, 612-622.

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  • High quality ion channel analysis on a chip with the NPC-technology
    Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.

    Assay and Drug Development Technologies, 2003, 1(5), 665-673.

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  • Ion channel drug discovery and research: The automated Nano-Patch-Clamp technology

    Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J.C., Fertig N.

    Current Drug Discovery Technologies, 2004, 1(1), 91-96.

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  • Microstructured apertures in planar glass substrates for ion channel research

    Fertig N., Meyer C., Tilke A., George M., Klau M., Sobotta C., Blick R.H., Behrends J.C.

    Channels and Receptors, 2003, 9(1), 29-40.

  • Microstructured glass chip for ion channel electrophysiology

    Fertig N., Meyer C., Blick R.H., Trautmann C., Behrends J.C. 

    Physical Review E, 2001, 64, 040901 R.

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  • Stable integration of isolated cell membrane patches in a nanomachined aperture: A step towards a novel device for membrane physiology

    Fertig N., Tilke A., Blick R.H., Kotthaus J.P., Behrends J.C., ten Bruggencate G. 

    APL, 2000, 77(8), 1218-20.

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  • Whole cell patch clamp recording performed on a planar glass chip
    Fertig N., Blick R.H., Behrends J.C. 
    Biophys. J., 2002, 82(6), 3056-62.

    2002_PCOnChipSmall

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  • The Port-a-Patch: The smallest patch clamp set up for high quality electrophysiology

    Brüggemann A., George M., Klau M., Beckler M., Steindl J., Behrends J., Fertig N.

    HEKA impulse 03, 2005, 2-4.

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  • Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles

    Kirchner C., Liedl T., Kudera S., Pellegrino T., Munoz J. A., Gaub H.E., Stoelzle S., Fertig N., Parak W.J.

    Nano Lett., 2005, 5(2), 331-338.

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  • High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation

    Sondermann M., George M., Fertig N., Behrends J.C.

    Biochimica et Biophysica Acta. 1758, 2006, 545–551.

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  • Microchip technology for automated and parallel patch clamp recording

    Brüggemann A., Stoelzle S., George M., Behrends J.C., Fertig N.

    Small, 2006, 2(7), 840 – 846.

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  • Automated ion channel screening: patch clamping made easy

    Farre C., Stoelzle S., Haarman C., George M., Brueggemann A., Fertig N.

    Expert Opinion Therapeutic Targets, 2007, 11(4), 557-565.

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  • Book chapter: Planar Patch Clamping

    Behrends, J.C., Fertig, N.

    Patch Clamp Analysis – Advanced Techniques, Series: Neuromethods, Springer, 2007, 38, 411-433.

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  • Electrophysiological assessment of HERG blockade: Comparative study using automated and conventional patch clamp systems

    Yook Y., Kim J., Cho H., Moon H., Kwak B.

    Toxicology Letters, 2007, 172 (Suppl.1), S98-S99.

  • Measuring Interference of Drug-Like Moleculeswith the Respiratory Chain: Toward the Early Identification of Mitochondrial Uncouplers in Lead Finding

    Stock U, Matter H, Diekert K, Dörner W, Dröse S, Licher T.

    Assay Drug Dev Technol. 2013 Aug 30.

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  • Functional significance of thermosensitive transient receptor potential melastatin channel 8 (TRPM8) expression in immortalized human corneal endothelial cells

    Mergler S, Mertens C, Valtink M, Reinach PS, Castelo Székely V, Slavi N, Abdelmessih S, Türker E, Fels G and Pleyer U.

    Exp Eye Res. 2013 Nov;116:337-49. doi: 10.1016/j.exer.2013.10.003. Epub 2013 Oct 14

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  • Effect of flavonoids on the phase separation in giant unilamellar vesicles formed from binary lipid mixtures.

    Ostroumova OS, Chulkov EG, Stepanenko OV, Schagina LV.

    Chem Phys Lipids. 2013 Dec 17. pii: S0009-3084(13)00167-9. doi: 10.1016/j.chemphyslip.2013.12.005.

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  • Monoacylglycerols Activate TRPV1 – A Link between Phospholipase C and TRPV1

    Zygmunt PM, Ermund A, Movahed P, Andersson DA, Simonsen C, Jönsson BA, Blomgren A, Birnir B, Bevan S, Eschalier A, Mallet C, Gomis A, Högestätt ED

    PLoS One. 2013 Dec 2;8(12): e81618


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  • Enhanced adsorption of Ca-ATPase containing vesicles on a negatively charged solid supported membrane for the investigation of membrane transporters

    Sacconi A., Moncelli MR., Mergheri G., Tadini-Buoninsegni F.

    Langmuir. 2013 Oct 16, Epub

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  • Differential Effects of the β‐Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1‐ and SQT2‐Mutant Channels Journal of Cardiovascular Electrophysiology

    Bodi I, Franke G, Pantulu ND, Wu K, Perez-Feliz S, Bode C, Zehender M, Zur Hausen A, Brunner M and Odening K.

    J Cardiovasc Electrophysiol,  2013, DOI: 10.1111/jce.12178

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  • Red cell investigations: Art and artefacts
    Minetti G, Egée S, Mörsdorf D, Steffen P, Makhro A, Achilli C, Ciana A, Wang J, Bouyer G, Bernhardt I, Wagner C, Thomas S, Bogdanova A, Kaestner L

    Blood reviews,  2013 Mar; 27(2):91-101.


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  • Automated Planar Patch-Clamp

    Milligan, C. J., & Möller, C.

    Ion Channels. Humana Press, 2013. 171-187.

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  • Minimized cell usage for stem cell-derived and primary cells on an automated patchclamp system

    Becker N, Stoelzle S, Göpel S, Guinot D, Mumm P, Haarmann C, Malan D, Bohlen H, Kossolov E, Kettenhofen R, George M, Fertig N, Brüggemann A.

    J Pharmacol Toxicol Methods 2013 XXX; ARTICLE IN PRESS

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  • Crystal structure and functional mechanism of a human antimicrobial membrane channel

    Songa C, Weichbrodt C, Salnikov ES, Dynowski M,Forsberg BO, Bechinger B, Steinem C, de Groot BL, Zachariae U and Zeth K.

    Proc Natl Acad Sci U S A. 2013 March 19; 110(12): 4586–4591.

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  • Establishment of a Secondary Screening Assay for P/Q-Type Calcium Channel Blockers

    Hermann D, Mezler M, Swensen A, Bruehl C, Obergrußberger A, Wicke K, Schoemaker H, Gross G, Draguhn A and Nimmrich V.

    Comb Chem High Throughput Screen 2013.

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